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First Four (Dayton, OH)
| Game | Winner | Reasoning |
| UMBC vs. Howard | UMBC | Slight favorite (-1.5); better overall resume |
| NC State vs. Texas | NC State | ACC experience edge; -1.5 spread |
| Lehigh vs. Prairie View A&M | Lehigh | -3.5 favorite; Patriot League champion |
| SMU vs. Miami (OH) | SMU | Despite Miami OH's 31-1 record, SMU -6.5 is substantial |
East Region (Washington, DC)
Round of 64
| Matchup | Winner | Score |
| (1) Duke vs. (16) Siena | Duke | 88-54 |
| (8) Ohio State vs. (9) TCU | TCU | 72-68 |
| (5) St. John's vs. (12) Northern Iowa | St. John's | 65-58 |
| (4) Kansas vs. (13) Cal Baptist | Kansas | 78-62 |
| (6) Louisville vs. (11) South Florida | Louisville | 74-66 |
| (3) Michigan State vs. (14) North Dakota State | Michigan State | 80-59 |
| (7) UCLA vs. (10) UCF | UCF UPSET | 71-68 |
| (2) UConn vs. (15) Furman | UConn | 82-61 |
Round of 32
| Matchup | Winner |
| (1) Duke vs. (9) TCU | Duke |
| (5) St. John's vs. (4) Kansas | St. John's |
| (6) Louisville vs. (3) Michigan State | Michigan State |
| (10) UCF vs. (2) UConn | UConn |
Key: St. John's (KenPom #16, AdjD #12, Pitino coaching) edges Kansas (10 losses, Peterson hobbled).
Sweet 16
| Matchup | Winner |
| (1) Duke vs. (5) St. John's | Duke |
| (3) Michigan State vs. (2) UConn | UConn |
Elite Eight
| Matchup | Winner |
| (1) Duke vs. (2) UConn | Duke |
Key: Cameron Boozer (22.7 PPG, 10.2 RPG) is the best player on the floor. Duke's KenPom #1 ranking and AdjD #2 contain UConn's inconsistent offense (AdjO #30).
East Region Champion: Duke (1)
West Region (San Jose, CA)
Round of 64
| Matchup | Winner | Score |
| (1) Arizona vs. (16) LIU | Arizona | 95-52 |
| (8) Villanova vs. (9) Utah State | Utah State | 68-63 |
| (5) Wisconsin vs. (12) High Point | Wisconsin | 75-61 |
| (4) Arkansas vs. (13) Hawaii | Arkansas | 82-64 |
| (6) BYU vs. (11) NC State | BYU | 79-74 |
| (3) Gonzaga vs. (14) Kennesaw State | Gonzaga | 84-58 |
| (7) Miami (FL) vs. (10) Missouri | Missouri UPSET | 73-71 |
| (2) Purdue vs. (15) Queens | Purdue | 90-62 |
Round of 32
| Matchup | Winner |
| (1) Arizona vs. (9) Utah State | Arizona |
| (5) Wisconsin vs. (4) Arkansas | Arkansas |
| (6) BYU vs. (3) Gonzaga | Gonzaga |
| (10) Missouri vs. (2) Purdue | Purdue |
Sweet 16
| Matchup | Winner |
| (1) Arizona vs. (4) Arkansas | Arizona |
| (3) Gonzaga vs. (2) Purdue | Purdue |
Elite Eight
| Matchup | Winner |
| (1) Arizona vs. (2) Purdue | Arizona |
Key: Arizona's depth (7 players averaging 8.7+ PPG) and elite defense (#3) neutralize Purdue's #2 offense. Purdue's defense (#36) is the weak link.
West Region Champion: Arizona (1)
Midwest Region (Chicago, IL)
Round of 64
| Matchup | Winner | Score |
| (1) Michigan vs. (16) UMBC | Michigan | 82-49 |
| (8) Georgia vs. (9) Saint Louis | Saint Louis | 70-66 |
| (5) Texas Tech vs. (12) Akron | Akron UPSET | 74-71 |
| (4) Alabama vs. (13) Hofstra | Alabama | 89-78 |
| (6) Tennessee vs. (11) SMU | Tennessee | 66-61 |
| (3) Virginia vs. (14) Wright State | Virginia | 72-53 |
| (7) Kentucky vs. (10) Santa Clara | Santa Clara UPSET | 75-72 |
| (2) Iowa State vs. (15) Tennessee State | Iowa State | 76-51 |
Round of 32
| Matchup | Winner |
| (1) Michigan vs. (9) Saint Louis | Michigan |
| (12) Akron vs. (4) Alabama | Alabama |
| (6) Tennessee vs. (3) Virginia | Virginia |
| (10) Santa Clara vs. (2) Iowa State | Iowa State |
Sweet 16
| Matchup | Winner |
| (1) Michigan vs. (4) Alabama | Michigan |
| (3) Virginia vs. (2) Iowa State | Iowa State |
Key: Michigan's #1 defense is the perfect antidote to Alabama's volume scoring (AdjD #67 is Alabama's fatal flaw). Iowa State's #4 defense grinds out Virginia.
Elite Eight
| Matchup | Winner |
| (1) Michigan vs. (2) Iowa State | Michigan |
Midwest Region Champion: Michigan (1)
South Region (Houston, TX)
Round of 64
| Matchup | Winner | Score |
| (1) Florida vs. (16) Lehigh | Florida | 85-55 |
| (8) Clemson vs. (9) Iowa | Iowa | 71-67 |
| (5) Vanderbilt vs. (12) McNeese | Vanderbilt | 80-65 |
| (4) Nebraska vs. (13) Troy | Nebraska | 64-52 |
| (6) North Carolina vs. (11) VCU | VCU UPSET | 68-64 |
| (3) Illinois vs. (14) Penn | Illinois | 88-62 |
| (7) Saint Mary's vs. (10) Texas A&M | Texas A&M UPSET | 69-66 |
| (2) Houston vs. (15) Idaho | Houston | 78-48 |
Round of 32
| Matchup | Winner |
| (1) Florida vs. (9) Iowa | Florida |
| (5) Vanderbilt vs. (4) Nebraska | Vanderbilt |
| (11) VCU vs. (3) Illinois | Illinois |
| (10) Texas A&M vs. (2) Houston | Houston |
Sweet 16
| Matchup | Winner |
| (1) Florida vs. (5) Vanderbilt | Florida |
| (3) Illinois vs. (2) Houston | Houston |
Key: Houston's #5 defense contains Illinois' #1 offense in a classic style clash — defense wins in March.
Elite Eight
| Matchup | Winner |
| (1) Florida vs. (2) Houston | Houston |
South Region Champion: Houston (2)
Final Four (Indianapolis, IN)
Semifinal 1: Duke (1) vs. Houston (2)
Winner: Duke. Cameron Boozer puts on a masterclass performance. Duke's #2 defense matches Houston's #5 defense, but Boozer's ability to score from all three levels is the difference-maker. Duke by 5.
Semifinal 2: Arizona (1) vs. Michigan (1)
Winner: Arizona. Arizona's seven-man scoring attack breaks through Michigan's #1 defense through sheer depth and ball movement. Michigan's tallest-in-America lineup contests everything, but Arizona's balance and Tommy Lloyd's offensive scheming find gaps. Arizona by 3 in a classic.
🏆
Arizona Wildcats
Arizona 72 — Duke 68
Arizona's unmatched roster depth overwhelms a Duke team limited by the absences of PG Caleb Foster and C Patrick Ngongba. Tommy Lloyd's squad completes a 36-2 season and brings the first national championship to Tucson since 1997.
Why Arizona Wins It All
- KenPom Profile: #3 overall (AdjO #5, AdjD #3) — elite two-way balance matching every historical champion benchmark
- Depth: Seven players averaging 8.7+ PPG is unmatched; no single-player dependency
- Health: Fully healthy roster — major advantage over Duke (missing PG + C)
- Path: West Region is considered the softest; arrives at Final Four less battle-worn
- Momentum: Big 12 Tournament champions; peaked at the right time
- Coaching: Tommy Lloyd in 5th year; deep tournament preparation experience
- Historical: Matches ALL six items on the champion checklist
Why Not Duke?
Despite being KenPom #1 and the tournament favorite (+300), Duke's injuries to PG Caleb Foster and C Patrick Ngongba create fatal vulnerabilities against elite competition. The simulation agents identified this as the critical factor — Duke can beat anyone with Boozer, but sustaining a 6-game run without two starters is historically unprecedented for a champion.
Upset Special: Akron over Texas Tech
The most confident upset pick. Texas Tech lost season-long star JT Toppin to an ACL tear. Akron shoots 40%+ from 3PT with Tavari Johnson at 20 PPG. The spread (TTU -7.5) underestimates the Toppin impact.